ORCHARD PARK, N.Y. (AP) - Matt Leinart struggled in his debut for the quarterback-depleted Buffalo Bills, who closed the preseason with 35-13 loss to the Detroit Lions on Thursday night. Looking like someone who's had just three days practice, the 2004 Heisman Trophy winner went 3 for 10 for 11 yards and two interceptions before being yanked after five possessions. That represents a major concern for Buffalo (2-2), which scrambled to sign the 2006 first-round draft pick Sunday after losing its top two quarterbacks to injury. First-round draft pick EJ Manuel is recovering from a left knee injury, while veteran Kevin Kolb is out indefinitely with a concussion. Lions second- and third-string quarterbacks Shaun Hill and Kellen Moore threw two touchdown passes each in helping Detroit build a 35-3 lead at the half.